2013 Fiscal Year Final Research Report
Antiaging control and oxidative stress analysis induced by blue light in the oral area
| Project/Area Number |
24792045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
YOSHIDA Ayaka 神奈川歯科大学, 歯学研究科(研究院), 研究員 (00609414)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 青色光 / 歯肉線維芽細胞 / 活性酸素種 / 酸化ストレス |
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| Research Abstract |
In Ophthalmology, the protective goggle or antioxidants supplementation have already been applied to harmful effects of high-energy wavelength of blue light which is using in the tooth office bleaching and composite resin treatments. Blue light study of dentistry has lagged behind. Therefore, I examined the effect of blue light irradiation to the gingival fibroblasts and tissue which are the outside of treatments. It was suggested that the reactive oxygen species induced by the 5 min blue light irradiation and the first target of the irradiation was mitochondria. As a result, the cell proliferation was suppressed by the irradiation. Further, it was suggested that oxidative stress was induced by 15 min irradiation to the rat gingival tissue. N-acetyl-cysteine decreased the effect of blue light irradiation.
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