2013 Fiscal Year Final Research Report
The effective approach for treatment of Dry Syndrome
| Project/Area Number |
24792072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | TRPM8 / TRPV1 / 角膜 / ドライアイ / ドライマウス / 乾燥 |
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| Research Abstract |
In oro-facial region, it is well known that Dry-Eye, Dry-nose, Dry-mouth syndrome as DRY syndrome. Three regions, the ocular surface, the intraoral cavity and the intranasal cavity, require constant secretions to provide nourishment and a protective barrier to the external environment. For Dry-Eye, cornea primary afferent neurons that respond to drying of the ocular surface have been previously characterized and found to respond to innocuous cooling, menthol and hyperosmotic stimuli. In this project, I have focused on the desensitization of primary afferent neuron which decreased the BASAL tearing and performed whole project to know this modulatory mechanisms. As a result, TRPV1 agonist, Capsaicin suppressed the corneal TRPM8-related neural activity (desensitization). It is proposed that there were some interaction between TRPM8 channel and TRPV1 channel on corneal primary afferent.
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