2013 Fiscal Year Final Research Report
Development of novel treatment on masticatory muscle pain with TMD
| Project/Area Number |
24792116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
NOMA Noboru 日本大学, 歯学部, 准教授 (70386100)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 持続的咬筋収縮 / ATP |
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| Research Abstract |
The mean percentage of FG-labeled P2X3R-positive neurons was significantly increased in TG following successive IL-1beta injections into the MM for 7 days. Successive administration of an IL-1beta receptor-antagonist into the MM attenuated the increase of P2X3-IR cells in the TG. ATP release from MM after 300-g pressure stimulation of MM was also significantly enhanced after CMM. Administration into MM of the selective P2X3,2/3 receptor antagonist A-317491 attenuated the decrement of HWT in CMM rats. A significant increase in HWT was also observed at 30 min after A-317491 (60 µg) injection in IL-1beta-injected rats. These findings suggest that P2X3R expression associated with enhanced IL-1beta expression and ATP release in MM has a possible important role in MM mechanical hyperalgesia after excessive muscular contraction.
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[Journal Article] Immune and Endocrine Function in Patients with Burning Mouth Syndrome2013
Author(s)
Koike K, Shinozaki T, Hara K, Noma N, Okada-Ogawa A, Asano M, Shinoda M, Eliav E, Gracely RH, Iwata K, Imamura Y
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Journal Title
Clin J Pain
Volume: 30(2)
Pages: 168-73
Peer Reviewed
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[Journal Article] Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats2013
Author(s)
Teramoto K, Tsuboi Y, Shinoda M, Hitomi S, Abe K, Kaji K, Tamagawa T, Suzuki A, Noma N, Kobayashi M, Komiyama O, Urata K, Iwata K
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Journal Title
Eur J Oral Sci
Volume: 121(2)
Pages: 86-91
Peer Reviewed
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[Journal Article] Groupcognitive-behavioral intervention for patients with burning mouth syndrome2013
Author(s)
Komiyama O, Nishimura H, Makiyama Y, Iida T, Obara R, Shinoda M, Kobayashi M, Noma N, Abe O, De Laat A, Kawara M
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Journal Title
J Oral Sci
Volume: 55(1)
Pages: 17-22
Peer Reviewed
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[Journal Article] Quantitative evaluation of oral function in acute and recovery phase of idiopathic facial palsy ; a preliminary controlled study2013
Author(s)
Kato Y, Kamo H, Kobayashi A, Abe S, Okada-Ogawa A, Noma N, Kukimoto N, Omori H, Nakazato H, Kishi H, Ikeda M, Imamura Y
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Journal Title
Clin Otolaryngol
Volume: 38(3)
Pages: 231-6
Peer Reviewed
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[Journal Article] Pain intensity and psychosocial characteristics of patients with burning mouth syndrome and trigeminal neuralgia2012
Author(s)
Komiyama O, Obara R, Uchida T, Nishimura H, Iida T, Okubo M, Shimosaka M, Narita N, Niwa H, Shinoda M, Kobayashi M, Noma N, Abe O, Makiyama Y, Hirayama T, Kawara M
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Journal Title
J Oral Sci
Volume: 54(4)
Pages: 321-7
Peer Reviewed
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