Hydrothermal treatment of titanium implant surface with calcium promotes epithelial sealing

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792122
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu University (2013-2014); Fukuoka Dental College (2012)
• Principal Investigator: YAMAZOE Jyunichi 九州大学, 歯学研究科(研究院), 研究員 (30452717)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: カルシウム水熱処理 / インプラント

Outline of Final Research Achievements

Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. We aimed to investigate whether CaCl2 hydrothermal-treated (Ca-HT) Ti could promote sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with either Ca-HT implants (Ca-HT group), distilled water-HT implants (DW-HT group) or non-treated implants (Cont group). We also investigated the effect of Ca-HT on the attachment of rat oral epithelial cells (OECs). OEC adherence on Ca-HT Ti plates was stronger, with greater expression levels of adhesion proteins, compared with Cont and DW-HT groups. These results indicated that HT with CaCl2 improved the integration of soft tissue cells with Ti, which may facilitate the development of a soft tissue barrier around the implant.

Free Research Field

補綴・理工学