2013 Fiscal Year Final Research Report
Mechanisms of enhanced bone formation by the electrically polarized biomaterials
| Project/Area Number |
24792133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NOZAKI Kosuke 東京医科歯科大学, 生体材料工学研究所, 助教 (00507767)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 電気分極 / チタンインプラント / 表面改質 / オッセオインテグレーション / 骨伝導能 / マイクロCT |
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| Research Abstract |
To clarify the effect of electrically polarized titanium implant on the bone formation, we fabricated the polarized titanium implant coated with the titanium oxide through the micro-arc oxidation process. A comprehensive assessment using biomechanical, histomorphological and radiographic analyses in a rabbit model was performed on polarized and non-polarized implants. The polarized titanium implant surfaces accelerated the establishment of implant biomechanical fixation, compared with the non-polarized surfaces and enhanced bone-implant contact ratio. Thus, the polarized implant has a significant effect on the bone formation around titanium implant. We established the application of the electrical polarization process which modified titanium implant surface without additional substances.
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