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2013 Fiscal Year Final Research Report

Development of novel bone graft material by using scaffold-free cell construct

Research Project

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Project/Area Number 24792141
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOsaka University

Principal Investigator

SASAKI Jun-Ichi  大阪大学, 歯学研究科(研究院), 助教 (50530490)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords組織工学 / 生体材料学 / 骨再生 / 細胞集合体
Research Abstract

The objective of this study was to develop artificial bone graft materials by using scaffold-free three dimensional cell construct. We were successful to fabricate novel bone-like tissue which contained cartilage and mineralized matirices formed by the endochondral ossification. The matirals achieved in this study are expected to use as a novel biomaterial for bone regenerative medicine.

  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] 歯髄再生技術はここまで進化した 第3回 : 成長因子やスキャフォールドの応用2013

    • Author(s)
      佐々木淳一, 今里 聡
    • Journal Title

      日本歯科評論

      Volume: 73(12) Pages: 141-143

  • [Journal Article] 歯髄再生技術はここまで進化した 第2回 : 歯由来以外の細胞を用いた歯髄再生の試み2013

    • Author(s)
      佐々木淳一, 今里 聡
    • Journal Title

      日本歯科評論

      Volume: 73(11) Pages: 145-147

  • [Journal Article] 歯髄再生技術はここまで進化した 第1回 : 歯由来の細胞を用いた歯髄再生の試み2013

    • Author(s)
      佐々木淳一, 今里 聡
    • Journal Title

      日本歯科評論

      Volume: 73(10) Pages: 153-155

  • [Journal Article] Application of cyclic strain for accelerated skeletal myogenic differentiation of bone marrow-derived mesenchymal stromal cells with cell alignment2013

    • Author(s)
      Egusa H, Kobayashi M, Matsumoto T, Sasaki JI, Uraguchi S, Yatani H
    • Journal Title

      Tissue Engineering Part A

      Volume: 19(5-6) Pages: 770-782

    • Peer Reviewed
  • [Journal Article] In vitro reproduction of endochondral ossification using 3D mesenchymal stem cell construct2012

    • Author(s)
      Sasaki JI, Matsumoto T, Egusa H, Matsusaki M, Nishiguchi A, Nakano T, Akashi M, Imazato S, Yatani H
    • Journal Title

      Integrative Biology

      Volume: 4(10) Pages: 1207-1214

    • Peer Reviewed
  • [Journal Article] Surface characterization of alkali- and heat-treated Ti with or without prior acid etching2012

    • Author(s)
      An SH, Matsumoto T, Miyajima T, Sasaki JI, Narayanan R, Kim KH
    • Journal Title

      Applied Surface Science

      Volume: 258(10) Pages: 4377-4382

    • Peer Reviewed
  • [Journal Article] In vitro bioactivity evaluation of nanoand micro-crystalline anodic TiO2 : HA formation, cellular affinity and organ culture2012

    • Author(s)
      An SH, Matsumoto T, Sasaki JI, Miyajima T, Narayanan R, Imazato S, Kim KH
    • Journal Title

      Materials Science and Engineering C

      Volume: 32(8) Pages: 2516-2522

    • Peer Reviewed
  • [Journal Article] Comparative analysis of mouse induced pluripotent stem cells and mesenchymal stem cells during osteogenic differentiation in vitro

    • Author(s)
      Egusa H, Kayashima H, Miura J, Uraguchi S, Wang F, Okawa H, Sasaki JI, Saeki M, Matsumoto T, Yatani H
    • Journal Title

      Stem Cells and Development

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] 基質配向ハイドロゲルを応用した皮質骨様組織の構築2014

    • Author(s)
      佐々木淳一, 松本卓也, 今里 聡
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2014-03-04
  • [Presentation] 三次元細胞集合体内における血管内皮細胞の共培養2013

    • Author(s)
      佐々木淳一, 松本卓也, 今里 聡
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2013-11-26
  • [Presentation] 歯髄組織工学に向けた棒状三次元細胞集合体の作製2013

    • Author(s)
      佐々木淳一, 毛利有希子, 竹重文雄, 今里 聡
    • Organizer
      第138回日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-06-27
  • [Presentation] 三次元細胞集合体における骨/軟骨基質形成プロセスの解析2012

    • Author(s)
      佐々木淳一, 松本卓也, 毛利有希子, 吉本いつみ, 今里 聡
    • Organizer
      第10回日本再生歯科医学会学術大会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-09-02
  • [Presentation] 細胞集合体を用いた内軟骨性骨化In vitro 定量解析ツールの開発2012

    • Author(s)
      佐々木淳一, 松本卓也, 江草 宏, 矢谷博文, 今里 聡
    • Organizer
      第59回日本歯科理工学会学術講演会
    • Place of Presentation
      徳島市
    • Year and Date
      2012-04-15
  • [Remarks]

    • URL

      http://www.dma.jim.osaka-u.ac.jp/view?l=ja&u=2796&a2=0000007&k=%E4%BD%90%E3%80%85%E6%9C%A8&kc=1&o=affiliation&pp=50&sm=affiliation&sl=ja&sp=1

URL: 

Published: 2015-06-25  

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