The development of novel scaffold with dental implant

2013 Fiscal Year Final Research Report

• Project/Area Number: 24792162
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: UEMURA Naoya 大阪歯科大学, 歯学部附属病院, 助教 (50610309)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 再生医療

Research Abstract

The aim of this study is to evaluate the bone regeneration ability, as it can become the Trans Sectional Research eventually in bone regeneration medicine for clinical application, which the novel product of the bone substitute material (a-TCP and synthetic collagen and poly lactic acid) was put in the fresh socket with immediate implant after teeth extraction.
In the 24 year, we confirmed that the bone regeneration ability of the novel bone substitute material itself in the rat calvarial defect model. (Already presentation and paper published) In the 25 year, we put the novel bone substitute material in the fresh socket with immediate implant after teeth extraction in the dog mandible defect model to close to the clinical situation. Presently, in the middle of this process, we prepare for conference presentation and publish paper.

Research Products

• [Journal Article] Evaluation of Bone Regeneration by Porous Alpha-tricalciumphosphate/Atelocollagen Sponge Composite in Rat Calvarial Defects (2012)
  • Author(s): Arima Y, Uemura N, Hashimoto Y, Baba S, Matsumoto N
  • Journal Title: Orthodontic Waves Volume: 72 Pages: 23-29
  • Peer Reviewed
• [Journal Article] Evaluation of Bone Regeneration using Platelet-rich or Platelet-poor Plasma Combined with Autologous Mesenchymal Stem Cells (2012)
  • Author(s): Yasui K, Arima Y, Lee P, Tokuda T, Azumi E, Nishiura A, Ito T, Hashimoto Y, Uemura N, Baba S, Matsumoto N
  • Journal Title: Journal of Oral Tissue Engineering Volume: 11(1) Pages: 57-66
  • Peer Reviewed
• [Presentation] Bone Regeneration by Porous Alpha-Tricalciumphoshate/Synthesized Collagen Composite (2014)
  • Author(s): Uemura N, Hieda A, Hirose T, Kaida K, Ito T, Hashimoto Y, Baba S
  • Organizer: 92th General & Exhibition of IADR
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2014-06-26
• [Presentation] Alpha-tricalcium phosphate/atelocollagen sponge composite versus autogenous bone for repair of calvarial defects in rat models (2013)
  • Author(s): Lee P, Arima Y, Tokuda T, Ryao T, Nishiura A, Hashimoto Y, Uemura N, Baba S
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: 松本市
  • Year and Date: 2013-10-07
• [Presentation] 臨床応用に向けた合成高分子材料による歯槽骨再生について (2012)
  • Author(s): 上村 直也, 橋本典也, 有馬 良幸, 安井 憲一郎, 馬場 俊輔, 川添 堯彬
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-09
• [Presentation] Evaluation of Bone Formation of Combining α-TCP and Atelocollagen by 3D Image Construction (2012)
  • Author(s): Arima Y, Yasui K, Sakamoto F, Uemura N, Hashimoto Y, Baba S, Matsumoto N
  • Organizer: 100th FDI Annual World Dental Congress
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2012-08-29
• [Presentation] Evaluation of Bone Regeneration of Combining PolyPHG and α-TCP (2012)
  • Author(s): Uemura N, Arima Y, Yasui K, Hashimoto Y, Baba S, Kawazoe T
  • Organizer: 90th General Session & Exhibition of the IADR
  • Place of Presentation: Iguacu Fall, Brazil
  • Year and Date: 2012-06-21
• [Presentation] The 3D Image of Bone Formation of Combining Synthesize Collagen Polypeptide and α -TCP (2012)
  • Author(s): Uemura N, Arima Y, Yasui K, Hashimoto Y, BabaS, Kawazoe T
  • Organizer: 2012 Sino-Japan Dental Conference
  • Place of Presentation: Chengdu China
  • Year and Date: 2012-04-26