2013 Fiscal Year Final Research Report
Smoking-related epigenetic abnormalities in the development of oral cancer
| Project/Area Number |
24792176
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Masanobu 東京大学, 医学部附属病院, 講師 (10392333)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 口腔癌 |
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| Research Abstract |
Methylation status of smoking related genes (HOXA9, MT1M, NEFH, UCHL1) in non-cancerous esophageal mucosae and esophageal cancers was examined in normal oral mucosae, oral leukoplakias and oral squamous cell carcinomas. Methylation status of the four genes in 16 of normal oral mucosae, 24 of oral leukoplakias and 26 of oral squamous cell carcinomas were examined by Methylation-Specific PCR (MSP).The methylation levels of four genes were found to be highest in oral squamous carcinomas followed by oral leukoplakias.The methylation levels of oral normal mucosae (control) were significantly low.
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