Effect of low intensity pulsed ultrasound on bone formation.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792177
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Dokkyo Medical University (2014); The University of Tokyo (2012-2013)
• Principal Investigator: YUSKE Komiyama 獨協医科大学, 医学部, 助教 (90586471)
• Co-Investigator(Renkei-kenkyūsha): ABE Takahiro 東京大学, 医学部付属病院顎口腔外科歯科矯正歯科, 講師 (20383250)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 低出力超音波パルス / 骨芽細胞 / 破骨細胞 / 骨代謝

Outline of Final Research Achievements

Low intensity pulsed ultrasound stimulation is known to directly stimulate pre-osteoblastic cells to osteoblastogenesis, though increase the bone formation. In this study, we aimed to investigate the effect of LIPUS on bone metabolism, including effects on both osteoblasts and osteoclasts. LIPUS could enhance the osteoclastogenesis of pre-osteoclast under the addition of differentiation factor. Bone metabolism is understood to be controlled through signaling from both osteoblasts and osteoclasts. Osteoclast-to-osteoblast signaling may be also have important roll in the effect of bone formation by LIPUS.

Free Research Field

口腔外科学