2013 Fiscal Year Final Research Report
Construction of a new model of osteo invasion and a new technology by TNF-a inhibitor
| Project/Area Number |
24792180
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 顎骨浸潤 / マウス抜歯窩骨新生モデル |
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| Research Abstract |
Oral squamous cell carcinoma has strong local permeation ability and it is clinically important problems for the permeation to jawbone in particular. Therefore, using a mouse lower incisor tooth extraction model, we tried to build an jawbone permeation by oral squamous cell carcinoma model, and the purpose of this study is to restrain jawbone permeation by restraining a TNF-alpha signal deriving osteoclast. We performed the mouse using male nude mouse (KSN) of 10-weeks age and injected thing which dipped the cancer cell (HSC-3) cell into the collagen in the incisor extraction socket, and killed a mouse four weeks later. We gathered mandibular bone and confirmed a three-dimensional image in micro-CT and evaluated bone resorption by the jawbone permeation. However the jawbone permeation model was not to recognize jawbone permeation unfortunately.
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