Investigation of the genetic diversity of extracapsular spread of the cervical lymph node metastasis in oral squamous cell carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792181
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MICHIKAWA Chieko 東京医科歯科大学, 歯学部附属病院, 医員 (00622648)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 被膜外浸潤 / 頸部リンパ節転移 / 口腔癌 / 扁平上皮癌

Outline of Final Research Achievements

According to NCCN Clinical Practice Guidelines in OncologyTM, the extracapsular spread (ECS) of lymph node metastasis is one of the most significant factors for planning post-operative therapy in head and neck cancer. Although pathological status of ECS is considered to have various types, the details remain unclear. Therefore we use ECS as just one type of pathological status at present. In order to understand what kind of lymph nodes develop ECS and how ECS develops, I investigated the status of metastatic lymph nodes pathologically and morphologically in detail. Then I analyzed all available information about metastatic nodes and the correlation with prognosis to find the useful and simple classification of ECS. Finally I found that the patients with a specific nodes which develop ECS had lower survival rates regarding both overall survival and disease-free survival.

Free Research Field

医歯薬学