2013 Fiscal Year Final Research Report
Can anti-angiogenic drug improve prognosis in CDDP resistant cell of oral cancer?
| Project/Area Number |
24792208
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
ISHIBASHI Miki 大阪大学, 歯学研究科(研究院), 招聘教員 (40412051)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 抗血管新生 / 口腔癌 |
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| Research Abstract |
The aim of this study was to clarify the sensibility of anti-angiogenesis therapy in CDDP-resistant oral squamous cell carcinomas. Briefly, ANG-1, ANG-2, VEGF, CD31 were immunohistochemically examined in order to evaluate its correlation with 3 type of human oral squamous cell carcinoma cell lines. We did not find significant correlation immunohistochemically with ANG-1, ANG-2 between human oral squamous cell carcinomas and CDDP-resistant oral squamous cell carcinomas. The sensibility of chemoradiotherapy in human oral squamous cell carcinomas after chemo-radiotherapy depend on, suggesting the involvement of other factors.
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