2013 Fiscal Year Final Research Report
The role of metabotropic glutamate receptor 5 on the metastases in oral cancer
| Project/Area Number |
24792225
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | mGluR5 |
|---|
| Research Abstract |
mGluR5-specific antagonists, MPEP and MTEP inhibit the SDF-1/CXCR4 dependent-migration of the cells.Immunohistochemical analysis revealed that there was a significant association between CXCR4 and mGluR5 protein expression.Furthermore, the mGluR5 protein expression in clinical specimen was significantly associated with the lymph node metastases and the modes of invasion.Moreover conditioned media derived from the oral cancer cells acquiring SDF-1/CXCR4 system enhanced the migration of lymphatic endothelial cells, which was significantly suppressed by the treatment with MPEP or MTEP.Furthermore,induction of a lymphangiogenic factor, VEGF-C was specifically impaired by the treatment with these mGluR5 antagonists. These results suggested that mGluR5 promotes the lymph node metastases of oral cancer cells by the SDF-1/CXCR4 system via enhancement of cancer cell migration and induction of lymphangiogenesis by VEGF-C.
|
