The development of novel treatment for oral cancer targeted on glycoprotein of cell surface

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792228
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: ISHIKAWA Akiko 愛媛大学, 医学(系)研究科(研究院), 講師 (90444760)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔癌 / α-dystroglycan / LARGE / sialidase

Outline of Final Research Achievements

In both the oral squamous cell carcinoma cell lines and clinical specimens, it was identified that the structure in the glycosylation of α-dystroglycan (α-DG) on the cell surface changed. It was suggested that the LARGE might be an influential glycosyltransferase which involved in this structural change. Among the glycoside modifying enzymes that have been reported in other malignant tumors (MGAT3, MGAT5, NEU1, NEU3, Fut8), the expression level of NEU3 mRNA in oral cancer tissues was significantly higher than in normal mucosa tissues. Some specific glycoconjugates and enzymes for glycoside modification are considered to play a essential role in the process of oral cancer development.

Free Research Field

口腔癌