2013 Fiscal Year Final Research Report
Analysis of the mechanism of the condition of a patient formation, the progress of Sjogren's syndrome
| Project/Area Number |
24792230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Thサブセット / サイトカイン / ケモカイン |
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| Research Abstract |
It was intended to analyze it about the condition of the patient in the lesion local site of Sjogren's syndrome in this study. I examined the local existence of the Th subset in the lesion local site between the same patients between the permeation degree of the lymphocyte of the comparison with the physically unimpaired person and the SS.
It was strong to carry the role that was important to the onset not condition of the patient progress, and both Th1 and Th17 where it permeated around the ductal epithelium of the SS were suggested by this study. Furthermore, in addition to Th1 and Th17, the condition of the patient progressed in what Th2 and Tfh accumulated and it was particularly strong that Th2 and Tfh played an important role for the formation of the GC and was suggested.
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[Journal Article] Clinical characteristics of Mikulicz's disease as an IgG4-related disease
Author(s)
Moriyama M, Tanaka A, Maehara T, Ohyama Y, Shimizu M, Nakashima H, Hayashida JN, Shinozaki S, Kubo Y, Furukawa S, Kikuta T, Nakamura S
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Journal Title
DOI
Peer Reviewed
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