2013 Fiscal Year Final Research Report
Elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma due to epithelial-to-mesenchymal transition mediated by DeltaNp63
| Project/Area Number |
24792231
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ΔNp63 / 口腔扁平上皮癌 / 上皮ー間葉転換（EMT） / 浸潤・転移 |
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| Research Abstract |
The purpose in this study is elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma due to epithelial-to-mesenchymal transition (EMT) mediated by DeltaNp63.
As the results, It is suggested that DeltaNp63 downregulation induced EMT in oral squamous cell carcinoma. DeltaNp63 possibly involved in acquirement of the ability of the invasion, metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype.
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[Journal Article] Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype2014
Author(s)
Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinnno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura
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Journal Title
Clinical and Experimental Metastasis
Volume: 31(3)
Pages: 293-306
Peer Reviewed
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[Journal Article] Parotid gland myoepithelioma with remarkable cystic formation : A case report2013
Author(s)
Hiroe Kakehashi, Shintaro Kawano, Tamotsu Kiyoshima, Mayumi Shimizu, Masafumi Moriyama, Ryota Matsubara, Takahiro Kiyosue, Yuichi Goto, Hideki Shiratsuchi, Seiji Nakamura
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 25(2)
Pages: 183-188
Peer Reviewed
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[Journal Article] Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma2012
Author(s)
Ryota Matsubara, Shintaro Kawano, Toru Chikui, Takahiro Kiyosue, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinno, Tetsuji Nagata, Kazunari Oobu, Koichiro Abe, Seiji Nakamura
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Journal Title
Academic Radiology
Volume: 19(6)
Pages: 708-717
Peer Reviewed
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[Presentation] 口腔扁平上皮癌における IL-6 の発現と機能~抗癌剤抵抗性獲得への関与について~2014
Author(s)
神野哲平, 川野真太郎, 松原良太, 後藤雄一, 清島保, 丸瀬靖之, 神野彰子, 金子直樹, 坂本泰基, 橋口有真, 森山雅文, 大部一成, 杉浦剛, 中村誠司
Organizer
第67回 NPO法人日本口腔科学会学術集会
Place of Presentation
東京都新宿区
Year and Date
2014-05-08
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[Presentation] 口腔扁平上皮癌における IL-6 の発現と臨床病理学的所見との関連2014
Author(s)
神野哲平, 川野真太郎, 松原良太, 清末崇裕, 後藤雄一, 平野充広, 田中秀明, 丸瀬靖之, 今藤彰子, 森山雅文, 大部一成, 中村誠司
Organizer
第32回 日本口腔腫瘍学会総会
Place of Presentation
北海道札幌市
Year and Date
2014-01-24
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[Presentation] 口腔扁平上皮癌頸部転移に対する術後治療の有用性についての検討2014
Author(s)
金子直樹, 大部一成, 後藤雄一, 川野真太郎, 橋口有真, 松原良太, 神野哲平, 丸瀬靖之, 坂本泰基, 田中秀明, 杉浦剛, 中村誠司
Organizer
第32回 日本口腔腫瘍学会総会
Place of Presentation
北海道札幌市
Year and Date
2014-01-24
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[Presentation] 唾液腺悪性腫瘍の臨床病理学的検討2014
Author(s)
坂本泰基, 後藤雄一, 川野真太郎, 今藤彰子, 松原良太, 神野哲平, 丸瀬靖之, 金子直樹, 橋口有真, 大部一成, 杉浦剛, 中村誠司
Organizer
第32回 日本口腔腫瘍学会総会
Place of Presentation
北海道札幌市
Year and Date
2014-01-23
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[Presentation] 口腔扁平上皮癌高転移株より分離した上皮-間葉転換細胞の特性2013
Author(s)
平野充広, 川野真太郎, 松原良太, 清末崇裕, 後藤雄一, 神野哲平, 丸瀬靖之, 豊嶋健史, 北村亮二, 田中秀明, 大部一成, 中村誠司
Organizer
第17回 九州地区口腔癌研究会学術講演会
Place of Presentation
福岡県福岡市
Year and Date
2013-06-07
