2014 Fiscal Year Final Research Report
Research of genetic factor for CLP using association analysis of candidate genes
| Project/Area Number |
24792232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 口唇口蓋裂 / 関連解析 / 候補遺伝子 |
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| Outline of Final Research Achievements |
To identify the susceptibility genes of multifactorial disorders, the genome-wide association study is useful. Since the enormous number of sample is needed, I decided to use the locus-wide association study in this research. To select candidate genes, I focused on a change in the genetic manifestation at the time of palate organization of a mouse. Palate tissues around the formation period were taken out and genetic manifestation was analyzed using a DNA micro array. Many genes participated in the palate formation, and moreover the genetic manifested pattern was different in a hard palate and a velum. It was considered to develop the symptoms by different mechanisms in each pattern of cleft.
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| Free Research Field |
外科系歯学
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