2013 Fiscal Year Final Research Report
The analysis of the interaction between CCN3 and vascular genesis at the point of osteogenesis
| Project/Area Number |
24792235
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 口腔顎顔面再建外科学 / 組織再生 |
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| Research Abstract |
Several lines of evidence have demonstrated that the CCN family of proteins regulates differentiation of skeletal mesenchymal cells such as muscle cells, chondrocytes and osteoblasts. Various members of CCN family genes were expressed in osteoblastic cells, and the expression is regulated by TGF and BMP-2. These studies suggest that the CCN family of proteins is involved in regulation of osteoblast differentiation by interacting with members of the TGF superfamily. Therefore, we demonstrated that CCN3 associated with the Notch1 extracellular domain and inhibited myoblast differentiation through Notch signaling pathway, indicating the involvement of CCN3 in Notch signaling. Further, we reported that Notch signaling plays a role in BMP-2-induced osteoblast differentiation. These results prompted us to investigate the role of CCN3 in osteoblast differentiation and its involvement in the BMP and Notch signaling pathways (J.Biol.Chem., 288, 2013).
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