2014 Fiscal Year Final Research Report
To clalify the new regulator of cell-cell fusion of osteoclasts
| Project/Area Number |
24792252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University |
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Principal Investigator |
RYOTARO Iwasaki 慶應義塾大学, 医学部, 講師(非常勤) (30365390)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 骨代謝 / 細胞融合 / 破骨細胞 |
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| Outline of Final Research Achievements |
Osteoclasts are multinuclear giant cells derived from hematopoietic stem cells or monocyte/macrophage lineage cells in the presence of M-CSF and RANKL. The multinucleation of osteoclasts is induced by a cell-cell fusion of mononuclear osteoclasts. Recently, we have isolated DC-STAMP (Dendritic Cell Specific Transmenbrane Protein), a seven transmembrane protein, as an essential molecule for osteoclast/FBGC cell-cell fusion.
This time, we identified the multitransmembrane protein,osteoclast stimulatory transmembrane protein(OC-STAMP), and found that OC-STAMP was also required for osteoclast and FBGC cell-cell fusion.
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| Free Research Field |
骨代謝
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