The role of HIF-1 and BMP-2 in Temporomandibular joint osteoarthritis.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792285
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SHIRAKURA Maya 広島大学, 医歯薬保健学研究院(医), 助教 (70549013)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 軟骨 / 骨 / 代謝 / 低酸素 / 機械刺激

Outline of Final Research Achievements

Temporomandibular joint osteoarthritis (TMJ-OA) is a complex disease that affects both cartilage and subchondral bone. It is accompanied by loss of extracellular matrix (ECM) and may be affected by Bone Morphogenetic Protein 2 (BMP-2). We analyzed the effect of BMP-2 in both cartilage and subchondral bone in a TMJ-OA animal model that is deficient in biglycan and fibromodulin (DKO) using an explant culture system. As a result, the upregulation of both anabolic and catabolic genes in the WT and DKO TMJs treated with BMP-2 suggests that BMP-2 increases matrix turnover in the condyle and, further, that Bgn/Fmod could have protective roles in regulating this process.

Free Research Field

細胞生物学