2013 Fiscal Year Final Research Report
Studies on transcriptional reguration of D-dopachrome tautomerase in adipocytes
| Project/Area Number |
24792290
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | D-dopachrome tautomerase / 脂肪細胞 / 転写調節 / AMPK |
|---|
| Research Abstract |
Promoter region of gene encoding D-dopachrome tautomerase (DDT), an adipokine which improves obesity-induced insulin resistance, was found to be located between 200 bp upstream and 23 bp downstream of the first methionine codon. The transcriptional activity of DDT gene was induced by oxidative stress or serum starvation in preadipocytes. Furthermore, cAMP-activated protein kinase (AMPK) was found to be involved in the transcription.
|
Research Products
(3 results)
