2013 Fiscal Year Final Research Report
Analysis of epigenetic control of mandibular development during embryonic stage
| Project/Area Number |
24792293
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TERAO Fumie 九州大学, 歯学研究科(研究院), 助教 (10510018)
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| Research Collaborator |
UMEDA Mariko 九州大学, 病院, 医員
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 発生・分化 / 細胞・組織 / エピジェネティック / メッケル軟骨 |
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| Research Abstract |
Histone deacetylases (HDACs) have emerged as important regulators of growth and organogenesis in various tissues. Inhibition of HDAC activity by Trichostatin A repressed the formation of cartilage nodule in mandibular cell culture and the formation of Meckel's cartilage in mandibular organ culture. Knockdown of HDAC1 in the lateral region of mandibular organ caused asymmetric shape of Meckel's cartilage. These results indicate that HDAC plays an important role in pattern formation of rat mandibular process during embryonic stage.
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