2013 Fiscal Year Final Research Report
The analysis of the bone remodeling control mechanism by transcription factor IRF-4
| Project/Area Number |
24792297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 歯学 |
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| Research Abstract |
Interferon (IFN) is induced by interferon regulatory factors (IRFs) which act as a transcription factor. This factor is related to immunoreactions. Recently IRF-8, which is one of the IRFs, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor (M-CSF) and ligand for receptor activator of nuclear factor kappa B (RANKL). In this study, we investigated the effects of IRF-4 on RANKL- (or TNF-alpha-) induced osteoclastogenesis.
Bone marrow cells from mice were cultured with M-CSF and RANKL. During osteoclastogenesis, the expression level of NFATc1 and IRF-4 mRNA were increased significantly. Moreover, the same dynamic state was shown also in osteoclastogenesis under M-CSF and TNF-alpha existence. These results suggest that IRF-4 may involve the regulation of osteoclast precursors.
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