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2013 Fiscal Year Final Research Report

The analysis of the bone remodeling control mechanism by transcription factor IRF-4

Research Project

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Project/Area Number 24792297
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

KOHARA Haruka  長崎大学, 大学病院, 医員 (70623825)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords歯学
Research Abstract

Interferon (IFN) is induced by interferon regulatory factors (IRFs) which act as a transcription factor. This factor is related to immunoreactions. Recently IRF-8, which is one of the IRFs, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor (M-CSF) and ligand for receptor activator of nuclear factor kappa B (RANKL). In this study, we investigated the effects of IRF-4 on RANKL- (or TNF-alpha-) induced osteoclastogenesis.
Bone marrow cells from mice were cultured with M-CSF and RANKL. During osteoclastogenesis, the expression level of NFATc1 and IRF-4 mRNA were increased significantly. Moreover, the same dynamic state was shown also in osteoclastogenesis under M-CSF and TNF-alpha existence. These results suggest that IRF-4 may involve the regulation of osteoclast precursors.

  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane2014

    • Author(s)
      Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T
    • Journal Title

      The Scientific World Journal

      Volume: 2014 Pages: 1-7

    • Peer Reviewed
  • [Journal Article] Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo2013

    • Author(s)
      Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M, Takano-Yamamoto T
    • Journal Title

      Clinical and Developmental Immunology

      Volume: 2013 Pages: 1-8

    • Peer Reviewed
  • [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice2012

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
    • Journal Title

      Archives of Oral Biology

      Volume: 57(1) Pages: 36-43

    • Peer Reviewed
  • [Journal Article] Inhibitory Effect of Interferon-γ on Experimental Tooth Movement in Mice2012

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Journal Title

      Journal of Interferon & Cytokine Research

      Volume: 32(9) Pages: 426-431

    • Peer Reviewed
  • [Presentation] 小腸上皮 ATP 文会系によるカルシウム吸収調節機序の検討2014

    • Author(s)
      小原悠, 増山律子
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20140724-26
  • [Presentation] 矯正学的歯の移動時におこる歯根吸収に対する IFN-γ の影響2013

    • Author(s)
      小原悠, 北浦英樹, 吉松昌子, 藤村裕治, 森田幸子, 吉田教明
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本
    • Year and Date
      20131007-09
  • [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption2012

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Year and Date
      20121012-15
  • [Presentation] メカニカルストレスに対する歯根周囲組織における IFN-γ の影響2012

    • Author(s)
      小原悠, 北浦英樹, 吉松昌子, 藤村裕治, 森田幸子, 吉田教明
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      20120926-28
  • [Presentation] メカニカルストレスに対する IFN-γ の発現およびその影響2012

    • Author(s)
      小原悠, 北浦英樹, 吉松昌子, 森田幸子, 藤村裕治
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      新宿
    • Year and Date
      20120719-21

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Published: 2015-06-25  

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