2013 Fiscal Year Final Research Report
Effect of epigenetics and the expression of miRNAs on occlusal activity during the postnatal development of masticatory and tongue muscle
| Project/Area Number |
24792313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 咬合の欠如 / 咀嚼筋 / 生後発達 / エピジェネティクス / miRNA |
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| Research Abstract |
Epigenetics involves genetic control by mechanisms other than DNA sequence. These epigenetic mechanisms have ability to switch on or off various important genes.MicroRNAs (miRNAs) are single-stranded 19-25 nucleotide-long RNAs and have an important role in post-transcriptional gene expression.
In this study,the regulatory pathway of miR-1 plays a more prominent role during postnatal development in the masseter muscle than in the gastrocnemius muscle, whereas the regulatory pathway of miR-133a plays a more prominent role in gastrocnemius muscle than in the masseter muscle.
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