2013 Fiscal Year Final Research Report
The establishment of diagnostic method for caries risk using SNPs analysis and the development of genetic test
| Project/Area Number |
24792315
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
OHTA Masumi 鶴見大学, 歯学部, 助教 (40410047)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | う蝕感受性 / SNPs解析 / DLX3 / 小児 |
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| Research Abstract |
In this study, we investigated whether single nucleotide polymorphisms(SNPs) in DLX3 is associated with dental caries susceptibility in Japanese children. A total of 200 Japanese children age 5 to 6 years with or without caries were recruited. The association between an allele and caries experience as well as the genotype and caries experience was assessed by Chi-square analysis. In the SNPs analysis, both the alleles and the genotypes of rs 2278163 in DLX3 were associated with dental caries experience in S.mutans high level group. As a result, our findings suggest that rs 2278163 SNP of DLX3 might be associated with dental caries susceptibility in Japanese population.
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