2013 Fiscal Year Final Research Report

The establishment of diagnostic method for caries risk using SNPs analysis and the development of genetic test

Research Project

Project/Area Number	24792315
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Tsurumi University
Principal Investigator	OHTA Masumi 鶴見大学, 歯学部, 助教 (40410047)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	う蝕感受性 / SNPs解析 / DLX3 / 小児
Research Abstract	In this study, we investigated whether single nucleotide polymorphisms(SNPs) in DLX3 is associated with dental caries susceptibility in Japanese children. A total of 200 Japanese children age 5 to 6 years with or without caries were recruited. The association between an allele and caries experience as well as the genotype and caries experience was assessed by Chi-square analysis. In the SNPs analysis, both the alleles and the genotypes of rs 2278163 in DLX3 were associated with dental caries experience in S.mutans high level group. As a result, our findings suggest that rs 2278163 SNP of DLX3 might be associated with dental caries susceptibility in Japanese population.

(1 results)