2013 Fiscal Year Final Research Report
Research of marker gene expression by epigenetic control in human periodontal ligament fibroblasts
| Project/Area Number |
24792316
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 歯根膜線維芽細胞 / アルカリフォスファターゼ |
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| Research Abstract |
Alkaline phosphatase (ALP) gene is expressed strongly in human periodontal ligament fibroblasts. We examined the changes of the gene expression and activity by epigenetics control (by DNA methylation in particular) using a bisulfite sequence analysis of ALP promoter region.These results suggested that expression of ALP gene is not under the control of epigenetics, and the change of activity is affected by transcription factors.
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