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2013 Fiscal Year Final Research Report

Investigation of pathological changes induced by hyperglycemia or highly saturated fatty acid

Research Project

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Project/Area Number 24792325
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

KASHIWAGI Yoichiro  大阪大学, 歯学部附属病院, 医員 (20598396)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords歯周病 / 糖尿病 / 高血糖 / 歯肉上皮細胞
Research Abstract

Both diabetes and periodontal disease are chronic disease and as risk factors mutually that have an influence on pathologic complexity, the difficulty of the treatment. However, the details of the mechanism of the relation of these diseases are not well known enough because periodontal disease is an infectious disease, and diabetes is a metabolism abnormal disease. In this study, we investigated the effect of diabetic condition on human gingival epithelial cells.
The result of research revealed that high glucose condition induced the expression of inflammatory cytokine (IL-8 etc.) and Toll like receptor 2 elevating in vitro. In addition, we found that oxidative stress was involved in these high glucose effects. These findings may reveal the molecular mechanism of diabetic patients having periodontal disease.

  • Research Products

    (4 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Nicotine upregulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 ・ or porphyromonas gingivalis lipopolysaccharide via nicotinic acethylcholine receptor signaling2012

    • Author(s)
      Kashiwagi Y, Yanagita M, Kojima Y, Shimabukuro Y, Murakami S
    • Journal Title

      Arch Oral Biol

      Volume: 57(5) Pages: 483-90

    • Peer Reviewed
  • [Presentation] 高血糖状態が歯周組織構成細胞のIL-8 産生に及ぼす影響2012

    • Author(s)
      柏木陽一郎, 山田聡, 北村正博, 村上伸也
    • Organizer
      第55回秋季日本歯周病学会学術大会
    • Year and Date
      2012-09-23
  • [Presentation] ニコチンと高血糖の歯肉上皮細胞における自然免疫応答に及ぼす影響2011

    • Author(s)
      柏木陽一郎, 柳田学, 山田聡, 北村正博, 村上伸也
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Year and Date
      2011-09-24
  • [Presentation] 高血糖とニコチンが歯肉上皮細胞の自然免疫応答に及ぼす影響2010

    • Author(s)
      柏木陽一郎, ほか
    • Organizer
      第25回糖尿病合併症学会
    • Year and Date
      2010-10-22

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Published: 2015-06-25  

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