2013 Fiscal Year Final Research Report
Identification of factors to differentiate into periodontal ligament cells
Project/Area Number |
24792326
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Periodontal dentistry
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Research Institution | Osaka University |
Principal Investigator |
OZASA Masao 大阪大学, 歯学部附属病院, 医員 (20624563)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 歯根膜 / 幹細胞 |
Research Abstract |
Gene expression of plap-1 (Periodontal Ligament Associated Protein-1) was induced by the mineralization inducing culture in canine adipose tissue-derived stem cells. On the other hand, activation of HIF-1 alpha by hypoxic culture or treatment of reagents resulted in up-regulation of PLAP-1 expression in periodontal ligament cells. Furthermore, secreted factors from periodontal ligament cells stimulated the gene expression of periostin in adipose tissue-derived stem cells. These results partly revealed the mechanisms that promote the differentiation of stem cells into periodontal ligament cells.
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Research Products
(5 results)
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[Journal Article] Periodontal tissue regeneration by transplantation of adipose tissue-derived multi-lineage progenitor cells2014
Author(s)
Masao Ozasa, Keigo Sawada, Tomoaki Iwayama, Satomi Yamamoto, Chiaki Morimoto, Hanayuki Okura, Akihumi Matsuyama, Hiroshi Komoda, Chun Man Lee, Yoshiki Sawa, Masahiro Kitamura, Tomoko Hashikawa, Masahide Takedachi, Shinya Murakami
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Journal Title
Inflammation and Regeneration
Volume: vol.34
Pages: 109-116
Peer Reviewed
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[Presentation] 脂肪組織由来未分化間葉系幹細胞を用いた新規歯周組織再生療法の経時的評価2012
Author(s)
沢田啓吾, 竹立匡秀, 小笹匡雄, 岩山智明, 野崎剛徳, 市川朋生, 前田憲一郎, 田内拓史, 三木康史, 大原廣之, 伊山舜吉, 安齋純, 永安利江, 寺嶋昭夫, 北村正博, 村上伸也
Organizer
第30回日本骨代謝学会
Place of Presentation
東京都新宿区
Year and Date
2012-07-21
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[Presentation] 犬実験的歯周病モデルを用いた脂肪組織由来未分化間葉系幹細胞および FGF-2 の移植による歯周組織再生効果2012
Author(s)
沢田啓吾, 竹立匡秀, 小笹匡雄, 岩山智明, 野崎剛徳, 市川朋生, 前田憲一郎, 田内拓史, 三木康史, 大原廣之, 伊山舜吉, 安齋純, 永安利江, 寺嶋昭夫, 北村正博, 村上伸也
Organizer
第11回日本再生医療学会総会
Place of Presentation
神奈川県横浜市
Year and Date
2012-06-12