2013 Fiscal Year Final Research Report
Development of photosensitizer with urea-Establishment of periodontal treatment combined with Er:YAG laser.
| Project/Area Number |
24792329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | レーザー / 歯周病 / LPS |
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| Research Abstract |
In recent years, there has been growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this study was to acquire an effective Er:YAG laser treatment with photosensitizer and evaluate the effects of antimicrobial photodynamic therapy(aPDT) with urea-containing reagent as photosensitizer for periodontal treatment.
It was comfirmed that the concentration of urea the most effectively involved in tarter removement was 5% urea.With urea-containing reagent application, the number of P.gingivalis decreased with increasing Er:YAG laser irradiation time in vitro. Laser with photosensitizer reagent group had a higher LPS elimination efficiency with increasing energy density,there was no significant difference between laser group and laser with photosensitizer reagent group though.
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