2013 Fiscal Year Final Research Report
Basic study aimed at the control of insulin resistance induced periodontal inflammation that target miRNA
| Project/Area Number |
24792331
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YAMASHITA Akiko 広島大学, 医歯薬保健学研究院, 助教 (70511319)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 歯周病 / メタボリックシンドローム |
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| Research Abstract |
RAW264.7, a murine macrophage cell line and differentiated 3T3-L1 adipocytes were co-cultured. I analyzed miRNA differentially expressed in adipocytes when co-cultured with macrophages in the presenceof LPS. miRNA differentially expressed in adipocytes were analyzed by the microarray method following 4,8,12 and 24h stimulation with LPS. I compared these results with previously reports. (Yamashita A.et al., Int J Obese.,2008),extracted the data of revelant miRNA about vascular involvement and insulin resistance. The revalant miRNA about inflammation, metabolism and vascular involvement expression were significantly up and down regulated.
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