2013 Fiscal Year Final Research Report
Foundation of infection control strategy for implantitis with nanonetwork structure
| Project/Area Number |
24792345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | インプラント周囲炎 / 表面性状 / 硬組織分化 |
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| Research Abstract |
Peri-implantitis can result in failure of implant osseointegration. Lipopolysaccharides (LPS) act as a chronic stimulus, maintaining peri-implant inflammation and thereby worsening the prognosis for implant osseointegration. The purpose of this study was to determine the effect of Porphyromonas gingivalis (P. gingivalis) LPS on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) on a nanonetwork titanium surface.
Titanium disks treated with 10 M NaOH solution and untreated control disks were incubated with BMMSCs and then exposed to P. gingivalis LPS. The BMMSCs on the nanonetwork titanium surface with nanonetwork structure had significantly higher cell proliferation and cell differentiation when exposed to P. gingivalis LPS at different concentrations than cells on the control surfaces.
The nanonetwork titanium surface had better endotoxin tolerance under P. gingivalis LPS exposure than non-modified surfaces.
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