2013 Fiscal Year Final Research Report
b-Cryptoxanthin regulates bone resorption related cytokine production in human periodontal ligaments cells.
| Project/Area Number |
24792358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OSEKO Fumishige 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10398406)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 予防医学 |
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| Research Abstract |
b-cryptoxanthin(b-cry) is a carotenoid that is contained in abundance in mandarin. b-cry not only inhibits carcinogenesis and has an antioxidative effect, it can also prevent osteoporosis and diabetes and can decrease body fat. This study suggest that b-cry may prevent bone resorption in periodontitis. In addition, inflammatory cytokine expression is decreased upon addition of b-cry before stimulation by P. gingivalis LPS in gingival fibroblasts. Production of inflammatory cytokines was suppressed by the inhibition of the activity of the ERK and p38 that are involved in intracellular signaling .It has been suggested that, b-cry is a carotenoid that can be expected therapeutic and preventive effect on periodontitis.
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