2013 Fiscal Year Final Research Report
The mechanism of oral flora selection by innate immunity.
| Project/Area Number |
24792370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
KAKUTA Erika 鶴見大学, 歯学部, 学部助手 (30585469)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Streptococcus mutans / ディフェンシン |
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| Research Abstract |
In this study, resistance against human beta-defensin 2 (hBD2) in Streptococcus mutans UA159 was investigated. In the dlt operon deleted mutant but not in the parent, viable bacterial count tended to decrease by hBD2 treatment in a dose-dependent manner, suggesting that the products of dlt operon might contribute to the peptide-resistance. Cell surface hydrophobicity was lower in the dlt-deleted strain than that in the parent. When cultured in sucrose-supplemented broth, both glass surface-adhesion and the glucan production in dlt deleted strain was lesser than that in the parent. Taken together, the bacterial surface characteristics including electrostatic charge and glucan production might affect to hBD2 resistance in S. mutans.
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[Journal Article] 社交不安障害と口臭症2013
Author(s)
八島章博, 福永裕子, 岡本真理子, 鴨井美帆, 園田華子, 中川幸香, 角田衣理加, 西岡千賀子, 湯浅茂平, 渡貫圭, 山本健, 前田伸子, 中川洋一
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Journal Title
日本口臭学会会誌
Volume: 4
Pages: 9-13
Peer Reviewed
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