2013 Fiscal Year Final Research Report
Development of a Vasohibin gene delivery system using nano/microbubbles and ultrasound
| Project/Area Number |
24800003
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
HORIE Sachiko 東北大学, 加齢医学研究所, 研究支援者 (90451640)
|
|---|
| Research Collaborator |
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Keywords | 癌 / Vasohibin / 遺伝子 / ナノ・マイクロバブル / 超音波 |
|---|
| Research Abstract |
Vasohibin-1 (VASH1) is an angiogenesis inhibitor. There are two transcripts of VASH1: one is the full length VASH1A and the other is splicing variant VASH1B. In this study, the anti-antitumor effects of VASH1A and VASH1B have been examined with a mouse solid tumor model using a tissue-specific gene delivery method using nano/microbubbels and ultrasound. Both VASH1A and VASH1B inhibited tumor growth exhibiting anti-angiogenic activity. However, more importantly, VASH1A stabilized neovessels while VASH1B pruned neovessels.
|
Research Products
(7 results)
