2013 Fiscal Year Final Research Report
Studies on the biofunction of seaweed extract for osteoporosis prevention
| Project/Area Number |
24800026
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
SOGO Nishimoto 東京海洋大学, 海洋科学技術研究科, 准教授 (70392066)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 生理活性 / 海藻 / 骨粗鬆症 / 細胞 |
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| Research Abstract |
In this study, we found that Gelidium elegans Katzing methanol extract (GME) suppressed the osteoclast differentiation.
To clarify this mechanism, we investigated the major and important gene expression in osteoclast differentiation. NFATc1 and JNK gene expression were decreased in osteoclast cultured with GME. It was revealed that GME was operated at the downstream of TRAF6. Moreover, the reduction of gene expression level of JNK and NFATc1 was induced by GME treatment.
These results from were suggested that GME carried out suppression of osteoclast differentiation in the intracellular signal transduction via RANK.
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