2013 Fiscal Year Final Research Report
investigation of geometical distortion for image analysis and development of classification in alzheimer's disease
| Project/Area Number |
24800089
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | 独立行政法人国立精神・神経医療研究センター |
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Principal Investigator |
MAIKUSA Norihide 独立行政法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 研究員 (80631069)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | MRI / 歪み補正 / アルツハイマー病 |
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| Research Abstract |
Alzheimer's disease (Alzheimer disease: AD) is the most serious dementia to affect cognitive functions. AD therapeutic drugs have been developing in the world, but it is pointed out for the enforcement to entail a vast cost with long time when it becomes the clinical trial. Image analysis using the MRI is effective for a clinical investigation evaluation of Alzheimer's disease, however the geometric distortion in the image ill-affect the reliability of image analysis. In this study, I developed correction method of geometrical distortion to improve this problem and this findings promote clinical investigation enforcement.
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[Journal Article] Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom2013
Author(s)
Maikusa N, Yamashita F, Tanaka K, Abe O, Kawaguchi A, Kabasawa H, Chiba S, Kasahara A, Kobayashi N, Yuasa T, Sato N, Matsuda H, Iwatsubo T
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Journal Title
Medical physics
Volume: 40(6)
Pages: 062303
DOI
Peer Reviewed
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