Using Structural Patterns of Microchannel Systems for Directional Control of Cell Migration

2014 Fiscal Year Final Research Report

• Project/Area Number: 24810002
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Microdevices/Nanodevices
• Research Institution: The University of Tokyo
• Principal Investigator: KUSHIRO Keiichiro 東京大学, 工学(系)研究科(研究院), 助教 (90632539)
• Project Period (FY): 2012-08-31 – 2015-03-31
• Keywords: 細胞移動 / 材料表面構造 / マイクロ流路 / マイクロパターン

Outline of Final Research Achievements

From the previous research of the representative, it was found that specific ２D micropatterns can enhance the cell migration speed or control the direction of movement. Based on these results, similar experimentation to manipulate cell migration using ３D microstructures were attempted in this project. Such cell migration guidance, without the use of chemical gradients or flow, have many advantages and applications, including the development of novel scaffolds for tissue engineering.

As for the achievements, it was found that specific surface structures promote a drastic increase in cell speed and persistence. Furthermore, it was found that the effect of the structures was different on normal cells and cancerous cells. Also, looking at the mechanotransduction signaling, it was found that the alignment of actin fibers due to the presence of the wall plays important roles. However, it has been difficult to identify surface structures that can control the directionality of cell movement.

Free Research Field

細胞工学・バイオマテリアル