2013 Fiscal Year Final Research Report

Statistical inference of lectin-carbohydrate binding

Research Project

Project/Area Number	24810010
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Genome biology
Research Institution	Kanazawa University
Principal Investigator	HIROSE Osamu 金沢大学, 電子情報学系, 助教 (30549671)
Project Period (FY)	2012-08-31 – 2014-03-31
Keywords	レクチン / 複合糖鎖 / 判別分析 / 機械学習
Research Abstract	Among carbohydrates which are polymers of monosaccharaides, glycoconjugates bind to glycoproteins and play important and various roles in the process of development, differentiation, immunity, canceration, and infection. Owing to the recent development of mass spectrometry and liquid chromatography, information about glycoconjugates and lectins has rapidly accumulated. The accumulation is expected to activate researches about glycoinformatics. In our study, we obtained the following results: (1) Collection and curation of amino acid sequences for lectins, (2) Prediction of lectins from amino acid sequences using local Fisher discriminant analysis, and (3) Inference of amino acid subsequences that characterizes whether proteins are lectins or not.

(3 results)