2013 Fiscal Year Final Research Report
Gold nanocluster-catalyzed environmentally benign bond formation
| Project/Area Number |
24850019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Institute for Molecular Science |
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Principal Investigator |
SUGIISHI Tsuyuka 分子科学研究所, 協奏分子システム研究センター, IMSフェロー (30636220)
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| Research Collaborator |
SAKURAI Hidehiro 分子科学研究所, 協奏分子システム研究センター, 准教授 (00262147)
PAWEENA Pongpipatt Mahidol大学, 学生
WARINTHON Chavasiri Mahidol大学, 教授
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 金ナノクラスター / 分子酸素 / ２－オキサゾリン / アミノアルコール |
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| Research Abstract |
From environmental point of view, waste-less methodologies are important through processes in organic synthesis. The character of gold nanocluster which can make the oxidations proceed with molecular oxygen was utilized, and the atom-economic C-C bond formation was accomplished in this study. In the presence of gold nanocluster Au:PVP and sodium carbonate under oxygen, reflux of the starting materials, or 2-(methyleneamino)ethanol derivatives afforded 2-oxazoline derivatives. The methodology might be applied to synthesis of bioactive compounds' fragments and synthesis of chiral ligands.
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