2013 Fiscal Year Final Research Report
IRES-dependent translational mechanism regulating tissue-specific replication of poliovirus
| Project/Area Number |
24870032
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Microbial Chemistry Research Foundation |
|---|
Principal Investigator |
SATOH Ryosuke 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員 (00635592)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Keywords | IRES / 翻訳開始機構 / ポリオウイルス / 組織特異性 / 宿主因子 |
|---|
| Research Abstract |
Poliovirus (PV) infection occurs as a result of destruction of motor neurons in the central nervous system (CNS). The aim of this study is to elucidate the fundamental process of IRES-dependent translational initiation involved in PV tissue tropism, through the identification and functional analysis of the host factors that regulate PV IRES (internal ribosome entry sites)-dependent translational initiation. In this study, we identified some host factor candidates that are specifically expressing and acting in nerve cells, utilizing biochemical/analytical chemical screening systems. This study is valuable to reveal the molecular basis of acquiring the CNS-specificity of PV infection through IRES-dependent translation.
|
