2013 Fiscal Year Final Research Report
Development of an atherosclerosis imaging probe for novel biomaker of vulnerble plaque
| Project/Area Number |
24890003
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIMIZU Yoichi 北海道大学, アイソトープ総合センター, 助教 (90634212)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 放射線 / 循環器 / 薬学 |
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| Research Abstract |
In this study, we evaluated the relationship of the biomolecules (Fatty acid-binding protein 5 (FABP5) and Thrombospondin-4 (TSP4)) detected by proteomics analysis to the progression of atherosclerotic state, and developed a novel imaging probe " 99mTc-HVPA" for early diagnosis of vulnerable plaque. FABP5 showed higher expression in Type IV legion (AHA classification) in the vessels of atherosclerotic model mice (ApoE -/- mice) and in the inflammatory (M1) macrophages. Furtheremore, we suceeded to developed 99mTc-HVPA which targeted to TSP4, and found that 99mTc-HVPA had a basic property as a SPECT imaging probe for diagnosis of vulnerable plaque.
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