2013 Fiscal Year Final Research Report
Recognition mechanisms of extracellular bacteria by intracellular sensors.
| Project/Area Number |
24890006
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAEKI Ayumi 北海道大学, 歯学研究科(研究院), 助教 (70638345)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | インフラマソーム / 口腔連鎖球菌 |
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| Research Abstract |
S. mutans, S. gordonii and S. sanguinis, as extracellular pathogens, which are normal inhabitants of the human oral cavity, induced IL-1b production by the dendritic cell line XS-106 cells derived from A/J mice in dose-dependent manners. The activity of S. sanguinis to induce IL-1b production was dependent on caspases-1 and NLRP3. Thus, this study suggests that oral streptococci activate NLRP3 inflammasome to produce IL-1b in murine dendritic cells.
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Research Products
(16 results)
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[Journal Article] Toll-like receptor 2 - mediated modulation of growth and functions of regulatory T cells by oral streptococci2013
Author(s)
Saeki A, Segawa T, Abe T, Sugiyama M, Arimoto T, Hara H, Hasebe A, Ohtani M, Tanizume N, Ohuchi M, Kataoka H, Kawanami M, Yokoyama A, Shibata K
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Journal Title
Mol Oral Microbiol
Volume: 28(4)
Pages: 267-80
DOI
Peer Reviewed
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[Journal Article] Mycoplasma removal from cell culture using antimicrobial photodynamic therapy2013
Author(s)
Hasebe A, Ishikawa I, Shamsul HM, Ohtani M, Segawa T, Saeki A, Tanizume N, Oouchi M, Okagami Y, Okano T, Shibata K
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Journal Title
Photomed Laser Surg
Volume: 1-7
Pages: 1-7
DOI
Peer Reviewed
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[Journal Article] Chlamydophila pneumoniae in human immortal Jurkat cells and primary lymphocytes uncontrolled by interferon-γ2013
Author(s)
Ishida K, Kubo T, Saeki A, Yamane C, Matsuo J, Yimin, Nakamura S, Hayashi Y, Kunichika M, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Shibata K, Yamaguchi H
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Journal Title
Microbes Infect
Volume: 15
Pages: 192-200
DOI
Peer Reviewed
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