2014 Fiscal Year Final Research Report
Role of insulin like growth factor-I on tooth morphogenesis
| Project/Area Number |
24890026
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2015-03-31
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| Keywords | IGF-I / 歯の形態制御 / 再生医療 |
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| Outline of Final Research Achievements |
It has been reported that the tooth size is extremely large in a patient with leprechaunism treated with insulin like growth factor-I (IGF-I), but the role of IGF-I on tooth morphogenesis remains unclear. In this study, we examined the function of IGF-I in the tooth morphogenesis. In both natural and bioengineered tooth germs, the size of the IGF-I-treated tooth germs was significantly larger than that of the control tooth germs. Moreover, the bioengineered tooth germs treated with IGF-I were increased in size, when they developed into teeth in the renal subcapsular layer of mice. Furthermore, larger teeth were erupted from the oral mucosa, when the bioengineered tooth germs treated with IGF-I were transplanted into the space of maxillae of mice. These findings suggest that IGF-I treatment technique allows for the generation of bioengineered teeth with increased size.
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| Free Research Field |
医歯薬学
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