Dual effect of selenium against x-ray irradiation: protective effects on normal cells and adjuvant effects on cancer cells.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24890034
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Gunma University
• Principal Investigator: YAMAZAKI CHIHO 群馬大学, 医学(系)研究科(研究院), 助教 (20506422)
• Project Period (FY): 2012-08-31 – 2015-03-31
• Keywords: セレン / 放射線治療

Outline of Final Research Achievements

Selenium has been reported its anti-oxidative effects as well as anticancer effects. We investigated the effects of selenium supplementation on x-ray irradiated carcinogenic and non-carcinogenic cells. Sodium selenite (50 nM) supplementation protected non-carcinogenic human esophageal cells against 2Gy X-ray irradiation, while induced cell death to carcinogenic cells.
Oral administration of different chemical forms of selenium to mice for 8 weeks showed metabolism and toxicity differ between selenium compounds. These suggest that selenium supplementation may be useful as adjuvant to enhance efficacy of radiation therapy, but effects and safety of each selenium compound must be evaluated first.

Free Research Field

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