2014 Fiscal Year Final Research Report
Hepatitis B virus evades DNA sensor-mediated IFN signaling pathways through interacting with STING
| Project/Area Number |
24890042
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA YASUO 東京大学, 医学部附属病院, 助教 (40422290)
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| Project Period (FY) |
2012-08-31 – 2015-03-31
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| Keywords | B型肝炎ウイルス / 自然免疫 / DNAセンサー |
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| Outline of Final Research Achievements |
It is not well understood how hepatitis B virus (HBV) evades DNA sensor-mediated IFN signaling pathways. In this study, we have shown that HBV polymerase inhibits STING (stimulator of interferon genes)-mediated IFN signaling pathways. Furthermore, the interaction between HBV polymerase and STING was observed. These results provide an additional molecular mechanism how HBV counteracts the innate immunity and may pave the way for the development of new antiviral therapy.
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| Free Research Field |
消化器病学
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