2013 Fiscal Year Final Research Report
Effect of fetal exposure to DEHP on nutrition status, hippocampus and hypothalamus in offspring
| Project/Area Number |
24890085
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
HAYASHI Yumi 名古屋大学, 医学(系)研究科(研究院), 助教 (30632707)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 衛生 / 栄養 / リスク評価 |
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| Research Abstract |
Exposure to di(2-ethylhexyl)phthalate (DEHP) during fetal periods decreased glucose concentration in neonatal mice, and lead to malnutrition. In addition, we examined the effect of DEHP on the brain, because glucose is significant source of nutrient. DEHP exposure changed the factors involved in memory. Furthermore, high fat diet also changed more factors, which may indicate that dietary environment effect on memory. Taken together, fetal exposure to DEHP may induce malnutrition in offspring, and effect on the brain during mature stage. We must carry out further research to clarify these mechanisms.
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