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2013 Fiscal Year Final Research Report

Exploration of a new biomarker for predicting prostate cancer prognosis using xenograft model

Research Project

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Project/Area Number 24890098
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKyoto University

Principal Investigator

TERADA Naoki  京都大学, 医学(系)研究科(研究院), 助教 (60636637)

Project Period (FY) 2012-08-31 – 2014-03-31
Keywords前立腺癌 / バイオマーカー / xenograft
Research Abstract

We have established four kinds of patient derived tumor tissue (PDTT) xenograft model of prostate cancer (KUCaP-1,-2,-3,-4). Our aim was to identify new biomarker for prostate cancer using PDTT xenograft model. We especially focused on KUCaP-3, which forms cyst containing high density tumor origin proteins. High sensitivity mass spectrometry analysis identified some kinds of biomarker candidate proteins. We are planning to investigate their function.

  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (10 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer2014

    • Author(s)
      Xu S, Zhang Z, Ogawa O, Yoshikawa T, Sakamoto H, Shibasaki N, Goto T, Wang L, Terada N
    • Journal Title

      Cell Biochem Biophys.

      Volume: (Epub ahead of print)

  • [Journal Article] Correlation of Sprouty1 and Jagged1 with Aggressive Prostate Cancer Cells with Different Sensitivities to Androgen Deprivation2014

    • Author(s)
      Terada N, Shiraishi T, Zeng Y, Aw-Yong KM, Liu Z, Takahashi S, Luo J, LupoldSE, Kulkarni P, Getzenberg RH
    • Journal Title

      J Cell Biochem.

      Volume: (Epub ahead of print)

    • DOI

      10.1002/jcb.24805.

  • [Journal Article] The expression profile of phosphatidylinositol in high spatial resolution imaging mass spectrometry as a potential biomarker for prostate cancer2014

    • Author(s)
      Goto T, Terada N, Inoue T, Nakayama K, Okada Y, Yoshikawa T, Miyazaki Y, Uegaki M, Sumiyoshi S, Kobayashi T, Kamba T, Yoshimura K, Ogawa O
    • Journal Title

      PLoS One

      Volume: 9(2) Pages: e90242

    • DOI

      10.1371/journal.pone.0090242.

  • [Journal Article] Novel constant-pressure irrigation technique for the treatment of renal pelvic tumors after ipsilateral ureterectomy2014

    • Author(s)
      Nakamura K, Terada N, Sugino Y, Yamasaki T, Matsui Y, Imamura M, Okubo K, Kamba T, Yoshimura K, Ogawa O
    • Journal Title

      Int J Urol.

      Volume: (Epub ahead of print)

    • DOI

      10.1111/iju.12386.

  • [Journal Article] A case of prostate carcinosarcoma successfully treated with combined modality therapy2013

    • Author(s)
      Matsuoka T, Sugino Y, Kobayashi T, Terada N, Yamasaki T, Matsui Y, Imamura M, Okubo K, Kamba T, Yoshimura K, Ogawa O
    • Journal Title

      Hinyokika Kiyo

      Volume: 59(11) Pages: 749-52

  • [Journal Article] Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing2013

    • Author(s)
      Zeng Y, Wodzenski D, Gao D, Shiraishi T, Terada N, Li Y, Vander Griend DJ, Luo J, Kong C, Getzenberg RH, Kulkarni P
    • Journal Title

      Cancer Res.

      Volume: 73(13) Pages: 4123-33

    • DOI

      10.1158/0008-5472.CAN-12-1343.

  • [Journal Article] Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer2013

    • Author(s)
      Kim JJ, Yin B, Christudass CS, Terada N, Rajagopalan K, Fabry B, Lee DY, Shiraishi T, Getzenberg RH, Veltri RW, An SS, Mooney SM
    • Journal Title

      J Cell Biochem.

      Volume: 114(6) Pages: 1286-93

    • DOI

      10.1002/jcb.24464.

  • [Journal Article] Overexpression of ETS-1 is associated with malignant biological features of prostate cancer2012

    • Author(s)
      Li B, Shimizu Y, Kobayashi T, Terada N, Yoshimura K, Kamba T, Mikami Y, Inoue T, Nishiyama H, Ogawa O
    • Journal Title

      Asian J Androl.

      Volume: 14(6) Pages: 860-3

    • DOI

      10.1038/aja.2012.107.

  • [Journal Article] Cyr61 is a potential prognostic marker for prostate cancer2012

    • Author(s)
      Terada N, Kulkarni P, Getzenberg RH
    • Journal Title

      Asian J Androl.

      Volume: 14(3) Pages: 405-8

    • DOI

      10.1038/aja.2011.149.

  • [Journal Article] Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness2012

    • Author(s)
      Terada N, Shiraishi T, Zeng Y, Mooney SM, Yeater DB, Mangold LA, Partin AW, Kulkarni P, Getzenberg RH
    • Journal Title

      Prostate

      Volume: 72(9) Pages: 966-76

    • DOI

      10.1002/pros.21501.

  • [Presentation] 高解像度質量顕微鏡を用いた前立腺癌組織のin situ脂質プロファイリング2014

    • Author(s)
      後藤崇之、寺田直樹、井上貴博、中山憲司、宮崎有、植垣正幸、吉川武志、小林恭、神波大己、吉村耕治、小川修
    • Organizer
      第23回泌尿器科分子細胞研究会
    • Place of Presentation
      山形(P-05)
    • Year and Date
      20140300
  • [Presentation] In situ lipid profiling of prostate cancer tissues using high resolution imaging mass spectrometry2014

    • Author(s)
      Takayuki Goto, Naoki Terada, Takahiro Inoue, Kenji Nakayama, Yu Miyazaki, Masayuki Uegaki, Takeshi Yoshikawa, Takashi Kobayashi, Tomomi Kamba, Koji Yoshimura, Osamu Ogawa
    • Organizer
      The 4th Congress of Asian Pacific Prostate Society
    • Place of Presentation
      沖縄(P-105)
    • Year and Date
      20140300
  • [Presentation] In situ lipid profiling of prostate cancer tissues using high resolution imaging mass spectrometry2013

    • Author(s)
      後藤崇之、寺田直樹、井上貴博、中山憲司、宮崎有、植垣正幸、吉川武志、小林恭、清水洋祐、神波大己、吉村耕治、小川修
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜(P-3297)
    • Year and Date
      20131000
  • [Remarks]

    • URL

      http://www.urology.kuhp.kyoto-u.ac.jp/

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Published: 2015-07-16  

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