2013 Fiscal Year Final Research Report
Regulation of Bcl-2 protein family prtoteins by virus infection
| Project/Area Number |
24890105
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
OKAMOTO Toru 大阪大学, 微生物病研究所, 助教 (80628595)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | ウイルス / 細胞死 |
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| Research Abstract |
Japanese Encephalitis virus (JEV) infection was found to degrade Mcl1, which is a prosurvival Bcl-2 protein family, through a proteasome dependent mechanism. Bcl-x deficient human cancer cell lines were induced cell death by JEV infection. On the other hands, Mcl1 deficiency was not induced cell death. These data suggested that JEV-infected cells were dependent on Bcl-x for their survive.
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Research Products
(4 results)
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[Journal Article] Enhanced Mcl1 stability can blunt stress-induced apoptosis, cause male sterility and promote tumorigenesis2014
Author(s)
Okamoto T, Coultas L, Metcalf D, van Delft M, Glasser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Hunag DCS
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Journal Title
Proc Natl Acad Sci U S A
Volume: 111
Pages: 261-266
Peer Reviewed
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