2013 Fiscal Year Final Research Report
Functional analysis of cohesin during CNS development
| Project/Area Number |
24890114
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
FUJITA Yuki 大阪大学, 医学(系)研究科(研究院), 特任助教 (常勤) (60631215)
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Keywords | 中枢神経 |
|---|
| Research Abstract |
Cohesin complex is composed of four subunits, Smc3, Smc1, Scc3, and Scc1, and has a role in sister chromatid cohesion, which is crucial for accurate chromosome segregation. Cohesin is also known to be involved in chromatin organization by forming chromatin loops at particular loci and regulate gene expression in postmitotic cells. Disruption of cohesin network results in cohesinopathies such as Cornelia de Lange syndrome. These diseases cause higher brain dysfunction, suggesting the role of cohesin in gene regulation rather than chromosome segregation. In this study, we tested the hypothesis that cohesin regulates genome organization and its deficiency leads to higher brain dysfunction.
|
