2013 Fiscal Year Final Research Report
Enhanced Osteogenesis of iPS Cells by Small Molecules
| Project/Area Number |
24890120
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | バイオロジー / 再生医療 |
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| Research Abstract |
The aim of this study was to investigate osteogenic differentiation capacity of iPS cells, and to examine effects of osteoblast-targeting small-molecules on the iPS cell osteogenesis.iPS cells produced robustly mineralized bone nodules that contained abundant calcium phosphate in vitro, and the osteogenesis can be enhanced by small molecules.iPS cell/gel scaffold construct by transplantation into the back of the SCID mouse skin showed apparent new bone formation without tumor formation.
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