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2013 Fiscal Year Final Research Report

Enhanced Osteogenesis of iPS Cells by Small Molecules

Research Project

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Project/Area Number 24890120
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthetic dentistry
Research InstitutionOsaka University

Principal Investigator

KAYASHIMA Hiroki  大阪大学, 歯学部附属病院, 医員 (50632121)

Project Period (FY) 2012-08-31 – 2014-03-31
Keywordsバイオロジー / 再生医療
Research Abstract

The aim of this study was to investigate osteogenic differentiation capacity of iPS cells, and to examine effects of osteoblast-targeting small-molecules on the iPS cell osteogenesis.iPS cells produced robustly mineralized bone nodules that contained abundant calcium phosphate in vitro, and the osteogenesis can be enhanced by small molecules.iPS cell/gel scaffold construct by transplantation into the back of the SCID mouse skin showed apparent new bone formation without tumor formation.

  • Research Products

    (1 results)

All 2013

All Presentation (1 results)

  • [Presentation] 移植に安全なiPS細胞技術を基盤とした新規骨増生術の開発2013

    • Author(s)
      萱島浩輝,江草宏,飯田務,明石喜裕,矢谷博文
    • Organizer
      第43回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      20130913-15

URL: 

Published: 2015-07-16  

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